Is there a genetic constitution that is weak or strong against oxidative stress?

First, let me briefly explain about "oxidative stress".

Oxidative stress is the ability of reactive oxygen species in the body to rust the body. Typical examples of reactive oxygen species are hydrogen peroxide and hypochlorous acid. Hydrogen peroxide is used to make bleach, and hypochlorous acid is used to deodorize and disinfect.

 

If you check the ingredients of bleaches, deodorants, and disinfectants used in the laundry and kitchen, you will probably find their names. In fact, these products are also made in our bodies. What they are made for is to kill bacteria that have invaded the body.

When bacteria enter the body, white blood cells swallow the bacteria, but swallowing alone does not kill the bacteria. This is where hydrogen peroxide, hypochlorous acid, and enzymes are used to break the bacteria into pieces and kill them. In this way, it is originally designed to protect our bodies from bacteria, but at the same time, it has the effect of rusting the body.
For example, if you get bleach on your hands, it will cause irritation. The same thing happens in the body.

This kind of force is called oxidative stress.

However, if the amount of active oxygen increases too much, oxidative stress will increase, and this oxidative stress will cause various diseases.
Genes and oxidative stress
As for whether there are people who are genetically predisposed to high or low oxidative stress, the genes related to oxidative stress have probably not been found yet.

However, as mentioned above, oxidative stress is involved in various diseases, some of which are genetic.
For example, there is a disease called diabetes.

When the lifestyle is disordered, the pancreatic cells that control blood sugar levels are damaged by oxidative stress. As a result, the blood glucose level remains high and the whole body is adversely affected by the oxidative stress, leading to complications such as arteriosclerosis, retinopathy, neuropathy, and nephropathy.

There is a familial form of diabetes that is not caused by lifestyle. This is caused by heredity, and oxidative stress is high as well. In other words, it can be said that oxidative stress is genetically high.
I would also like to talk about a disease called ulcerative colitis.

This is another disease in which genetic factors are said to be involved. Ulcerative colitis is an inflammatory disease that causes inflammation of the mucous membrane of the colon, resulting in ulcers and other problems. Inflammation means that oxidative stress is increased, as you can see from the bleaching agent mentioned earlier. People who suffer from this disease are also genetically predisposed to high oxidative stress, as in the case of diabetes.
I have given examples of diabetes and inflammatory diseases.

We can talk about whether the egg comes first or the chicken comes first with regard to genetic diseases, but it can be said that if these diseases are inherited, we are at risk of being born with a higher level of oxidative stress.

In other words, there is a connection between genetic diseases and oxidative stress.